4/12/2023 0 Comments Majka serial![]() Together, these results showed that combinations of the point mutations cannot further eliminate the checkpoint function of Rad4. ![]() ( B) Combination of F305S with E368K is lethal, consistent with the essential function of the third BRCT repeat in DNA replication. The C13Y-K56R and C13Y-E368K mutants grow normally, however, no significant enhancement of drug sensitivity was observed. Combination of K56R with E368K is lethal, suggesting that the replication function is affected. ( A) In order to search for an ideal rad4 mutation that can completely separate the checkpoint function from the DNA replication function of Rad4, C13Y, K56R and the previously described E368K (T aricani and W ang 2006) mutations were combined to see whether the combined mutations can further increase the drug sensitivity. ![]() Figure S2: The N-terminal C13Y and K56R mutations may have maximally eliminated the checkpoint function of Rad4.
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